Unlocking the Secrets to Healthy Aging: Podcast Episode with Dr. Wolfgang Brysch & Ann Louise Gittleman

• What Are the Podcast Episode Highlights?
• Who Is on the Podcast? Meet Our Experts
• How Does Aging Impact the Body?
• What Are Three Ways to Optimize Longevity?
• What Are the Key Nutrients to
• Support Aging and Brain Health?
• How Can You Optimize Neurological Health with iüVitalizer?
• Try a Trial Pack of iüVitalizer
• Where to Listen and Learn More
• Learn More About Dr. Wolfgang Brysch & Ann Louise Gittleman
• References

At iüLabs , we're excited to bring you an insightful discussion between Ann Louise Gittleman, "The First Lady of Nutrition," and Dr. Wolfgang Brysch, our co-founder and Chief Scientific and Medical Advisor. Dr. Brysch, a neurobiologist with 26 patents to his name, has dedicated his life’s work to exploring the keys to healthy aging, inflammation control, and optimizing human performance.

In this thought-provoking episode, Dr. Brysch takes us behind the scenes of a revolutionary discovery: a ground-breaking molecule initially created for treating Muscular Dystrophy in children. When faced with long approval delays, he turned to nature’s own compounds, leading to unexpectedly powerful results. Ann Louise and Dr. Brysch dive deep into the science of aging, covering everything from muscle loss and sarcopenia to Parkinson’s disease, while also examining how oxidative stress affects dopamine-producing neurons. They also touch on crucial topics like Long COVID, the effects of vaccines, and innovative wellness solutions like methylene blue.

Tune in for an enlightening conversation that’s sure to reshape how we think about aging, health, and the future of natural wellness!

 

What Are the Podcast Episode Highlights?

• The role of oxidative stress in neurodegenerative diseases

• How mitochondrial health influences longevity

• Natural compounds that support brain function and muscle preservation

• The benefits of methylene blue in cognitive function and energy production

• Strategies to combat aging-related inflammation and oxidative damage

• Insights into Long COVID and its effects on neurological health

Who Is on the Podcast? Meet Our Experts

Ann Louise Gittleman, PhD, CNS

A leading nutritionist and bestselling author, Ann Louise Gittleman is renowned for her work in functional medicine, environmental health, and women's wellness. Known as "The First Lady of Nutrition," she continues to pioneer breakthroughs in holistic health and longevity.

Dr. Wolfgang Brysch

Dr. Brysch is a neurobiologist, medical doctor, and co-founder of iüLabs. With over 30 years of experience, he has dedicated his research to aging, inflammation, and performance optimization, holding 26 patents in the field.

 

How Does Aging Impact the Body?

Aging is a complex process that gradually affects nearly every system in the body. As we age, the body's ability to repair and regenerate cells decreases, leading to reduced cellular function and a slower recovery from injury or stress. One of the most significant contributors to the aging process is oxidative stress, which occurs when there is an imbalance between free radicals and antioxidants in the body. This imbalance causes cellular damage and accelerates the breakdown of tissues, which can lead to chronic conditions and a general decline in health.

At the core of many age-related issues is mitochondrial dysfunction. Mitochondria, often referred to as the powerhouses of our cells, are responsible for producing the energy needed to fuel our daily activities. As we age, mitochondrial function declines, leading to reduced energy production, fatigue, and decreased physical and cognitive performance. This decline also plays a major role in the development of chronic diseases, such as heart disease, diabetes, and neurodegenerative conditions.

Chronic inflammation is another hallmark of aging. While inflammation is a natural immune response to injury or infection, prolonged or excessive inflammation can become detrimental. Over time, this chronic low-grade inflammation can damage tissues and organs, making the body more susceptible to conditions like arthritis, cardiovascular disease, and even certain cancers. This inflammatory response also accelerates muscle loss, known as sarcopenia, making it harder for older adults to maintain strength and mobility.

Hormonal changes also contribute to the aging process. For example, levels of key hormones like estrogen, testosterone, and growth hormone decrease with age, affecting everything from muscle mass to bone density and cognitive function. These hormonal shifts can lead to a range of symptoms, including weight gain, mood changes, decreased libido, and cognitive decline.

Dr. Brysch explains how these interconnected processes unfold over time and how they impact everything from muscle mass to brain health. While aging is inevitable, he emphasizes that there are strategies to slow down these processes, such as incorporating lifestyle changes, proper nutrition, regular physical activity, and natural compounds that support cellular function and reduce oxidative stress. By taking proactive steps, we can enhance our quality of life as we age and reduce the risk of developing debilitating conditions.

What Are Three Ways to Optimize Longevity?

Optimizing longevity isn’t just about living longer; it’s about maintaining vitality and mental clarity as we age. With the right combination of nutrients, lifestyle choices, and supplementation, we can slow down the aging process and promote better health. At iüLabs, we focus on three key strategies that can significantly enhance longevity: supporting mitochondrial health, reducing oxidative stress, and strengthening both muscle and cognitive function. Many of these ingredients can be found in our iüVitalizer (Energy & Focus) formula, designed to support your overall wellness.

 

1. Support Mitochondrial Health

Mitochondria, the powerhouses of our cells, are responsible for producing the energy required to sustain our bodies. As we age, mitochondrial function declines, leading to reduced energy levels, slower metabolism, and increased fatigue. Supporting mitochondrial health is essential to combat this decline and improve overall well-being. Nutrients like CoQ10 and NAD+ are critical in maintaining mitochondrial efficiency. CoQ10 aids in cellular energy production and acts as a powerful antioxidant, while NAD+ supports cellular repair and optimal DNA function. Additionally, alpha-lipoic acid is a potent antioxidant that enhances mitochondrial function and helps protect against age-related damage. Methylene blue further boosts mitochondrial health by improving energy production and protecting cells from oxidative damage. These powerful ingredients, found in iüVitalizer (Energy & Focus), promote longevity by enhancing cellular function, reducing fatigue, and optimizing overall vitality.

 

2. Reduce Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body, leading to cellular damage and accelerating the aging process. Reducing oxidative stress is essential for preventing age-related diseases, such as heart disease, cancer, and neurodegenerative conditions. A diet rich in antioxidants, including vitamin E, green tea extract, quercetin, resveratrol, and vitamin C, can help neutralize free radicals and protect cells from oxidative damage. Along with antioxidant-rich foods, fasting can be a powerful tool for reducing oxidative stress by promoting the body's natural detoxification and repair processes. Rhodiola Rosea extract, known for its adaptogenic properties, helps reduce oxidative damage and supports the body’s ability to handle stress, further contributing to longevity. Targeted supplementation with ingredients like NAD+, methylene blue, and alpha-lipoic acid—all featured in iüVitalizer (Energy & Focus)—can enhance antioxidant defenses and reduce oxidative stress at the cellular level, promoting a longer, healthier life.

3. Strengthen Muscle & Cognitive Function

Maintaining strong muscles and cognitive health is crucial for overall longevity and quality of life. As we age, muscle mass naturally declines (a condition known as sarcopenia), and cognitive function may also deteriorate. To preserve both, regular exercise and proper nutrition are essential. For muscle health, adequate protein intake and strength training exercises help maintain muscle mass and prevent physical decline. Magnesium citrate supports muscle function and helps prevent cramps, while glycine plays a role in muscle growth and repair. L-tyrosine, an amino acid, is essential for cognitive function and supports mental clarity and focus, especially under stress. To further optimize brain and muscle health, methylene blue supports cognitive function by enhancing brain circulation and protecting against neurodegenerative diseases.

For cognitive longevity, the inclusion of Ashwagandha extract offers neuroprotective benefits, reducing stress and promoting mental well-being. L-theanine and caffeine work synergistically to enhance focus and alertness without the jittery side effects of caffeine alone. Ginseng extract is another powerful adaptogen that can enhance mental clarity and cognitive performance. Additionally, vitamins like B6, B12, B3 (nicotinamide), and folic acid are essential for maintaining brain health, supporting neurotransmitter function, and promoting overall cognitive clarity. All of these ingredients are found in iüVitalizer (Energy & Focus), which is formulated to support both muscle strength and brain function, ensuring that we age with vitality and mental sharpness.

By focusing on mitochondrial health, reducing oxidative stress, and strengthening muscle and cognitive function, we can optimize longevity and ensure that we live a healthier, more vibrant life. At iüLabs, we believe that with the right combination of nutrients like vitamin B12, green tea extract, magnesium citrate, and quercetin, along with a balanced lifestyle, we can not only extend our lifespan but also improve the quality of our years as we age.

What Are the Key Nutrients to Support Aging and Brain Health?

• Methylene Blue – Enhances mitochondrial efficiency and brain function.
• Coenzyme Q10 (CoQ10) – Supports cellular energy production and heart health.
• NAD+ Precursors – Promote DNA repair and cellular longevity.
• Omega-3 Fatty Acids – Reduce inflammation and support cognitive function.
• Magnesium & B Vitamins – Essential for neurological health and stress management.

How Can You Optimise Neurological Health with iüVitalizer?

Dr. Brysch’s  incredible work has led to the development of iüVitalizer, a next-generation supplement designed to support mitochondrial health, reduce oxidative stress, and enhance cognitive performance. Formulated with precision, iüVitalizer integrates natural compounds to help optimise brain function, energy production, and longevity.

Try a Trial Pack of iüVitalizer

Curious about the benefits of iüVitalizer? Try a trial pack today and experience its powerful effects on energy, mental clarity, and overall well-being. 

Where to Listen and Learn More

Don’t miss this exciting episode! Listen to the podcast on:

• Apple Podcasts
• Spotify
• Google Podcasts
• Stitcher
• Your favourite podcast platform

Learn More About Dr. Wolfgang Brysch & Ann Louise Gittleman

The Host: Ann Louise Gittleman

Ann Louise Gittleman, PhD, CNS, is a trailblazing nutritionist, bestselling author, and one of the most influential voices in functional and integrative medicine. With a career spanning decades, she has been a driving force behind cutting-edge advancements in nutrition, detoxification, and women's health. Widely regarded as The First Lady of Nutrition, Dr. Gittleman has reshaped the way people think about diet, metabolism, and environmental toxins, challenging conventional wisdom with her research-backed insights. Her academic journey began at Columbia University’s Teachers College, where she earned her advanced degree in nutrition, later serving as the Chief Nutritionist at the renowned Pritikin Longevity Center. Her deep understanding of biochemical individuality and the intricate connections between diet, hormones, and detoxification has positioned her as a thought leader in the wellness industry.

A prolific author, Dr. Gittleman has penned over 35 books, many of which have become bestsellers, covering topics such as weight loss, immune health, and the hidden dangers of environmental toxins. Her groundbreaking work has been instrumental in bringing attention to the impact of heavy metals, parasites, and endocrine disruptors on overall health. As the host of The First Lady of Nutrition podcast, she continues to educate and inspire, featuring expert discussions on the latest science in longevity, functional medicine, and holistic well-being. Her influence extends far beyond her books and podcasts—she has appeared on major media outlets, served as a consultant for top health organizations, and helped shape the natural health movement. With an unwavering passion for empowering individuals to take charge of their health, Dr. Gittleman remains a leading voice in the field, advocating for smarter nutrition, cleaner living, and a proactive approach to aging gracefully.

The Guest: Dr. Wolfgang Brysch

Dr. Wolfgang Brysch is the Co-founder, Chief Scientific Officer, and Medical Advisor of iüLabs, where he spearheads the development of cutting-edge supplements and therapeutics designed to optimize health and longevity. With more than 30 years of clinical experience, he has earned recognition as a leader in the pharmaceutical and biotech industries. His academic foundation was built at Goettingen University in Germany and further refined at the University of Cambridge in the UK before he embarked on groundbreaking research at the prestigious Max-Planck Institute for Biophysical Chemistry. It was there that he honed his expertise in drug development, medical research, and the intricate mechanisms of aging, setting the stage for his pioneering work in therapeutic innovation. Over the course of his career, Dr. Brysch has devoted himself to exploring the complex interplay between biology and chemistry, developing novel therapies that address some of the most pressing health concerns of our time.  

A distinguished scientist and inventor, Dr. Brysch has co-invented 26 scientific patents that have helped shape new frontiers in pharmaceuticals and nutritional supplements. His research focuses on the powerful potential of plant-based compounds and their ability to support healthy aging, reduce inflammation, and enhance both physical and cognitive performance. As a driving force behind iüLabs, he ensures that every supplement formula is grounded in rigorous, evidence-based science, combining decades of expertise with a commitment to quality and efficacy. His role as a trusted advisor to the German Federal Ministry of Education and Research in matters related to COVID-19 medication further underscores his influence in the scientific community, particularly in the development of innovative treatments during global health crises. As iüLabs continues to push the boundaries of wellness, Dr. Brysch remains dedicated to leveraging the synergy between nature and science to create transformative health solutions, helping individuals achieve peak vitality and longevity.

References

---

1. Akinmoladun, A. F., & Gbadamosi, I. T. (2020). Methylene blue: A promising natural compound for neurological diseases. Journal of Neurological Disorders & Stroke, 5(1), 1–7. PubMed
2. Almeida, C. A., & Silva, M. E. (2021). Coenzyme Q10 supplementation: A potential approach for age-related diseases. Journal of Aging Research, 2021, 7864947. PubMed
3. Bhattacharya, S., & Das, S. (2021). The potential of mitochondrial modulation in the treatment of neurodegenerative diseases. Experimental Gerontology, 148, 111286. PubMed
4. Bogdanov, M., & Hyman, B. T. (2021). Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Current Alzheimer Research, 18(3), 276–284. PubMed
5. Bhat, R., & Choi, J. (2020). Methylene blue as a therapeutic agent in neurodegenerative diseases: A focus on Alzheimer's disease. Pharmacology & Therapeutics, 209, 107496. PubMed
6. Brysch, W. (2018, January 24). Questions to the CEO. MetrioPharm Blog. Retrieved from https://blog.metriopharm.com/en/2018/01/24/ask-the-ceo-1/
7. Brysch, W. (2019, February 19). MetrioPharm CEO Dr. Brysch as panel speaker at the European Life Science CEO Forum. MetrioPharm. Retrieved from https://www.metriopharm.com/de/News/2019/MetrioPharm-AG-Pressemitteilung-Februar2019.html
8. Brysch, W. (2020). Immune-modulating drug MP1032 with SARS-CoV-2 antiviral activity in vitro: A potential multi-target approach for prevention and early intervention treatment of COVID-19. ResearchGate. Retrieved from https://www.researchgate.net/profile/Wolfgang-Brysch
9. Brysch, W. (n.d.). Managing chronic fatigue in autoimmune conditions with vital nutrients. The Autoimmune RESET – Podcast. Retrieved from https://podtail.com/en/podcast/the-autoimmune-reset/managing-chronic-fatigue-in-autoimmune-conditions
10. Brysch, W. (n.d.). Profile and biography. Bloomberg Markets. Retrieved from https://www.bloomberg.com/profile/person/16237730
11. Brysch, W. (n.d.). Research profile. ResearchGate. Retrieved from https://www.researchgate.net/profile/Wolfgang-Brysch
12. Charvin, D., & Guillon, M. (2020). Methylene blue: A novel approach for neurodegenerative diseases. Cellular and Molecular Life Sciences, 77(11), 2209–2224. PubMed
13. Ghosh, S., & Ghosh, S. (2020). Cognitive decline in aging and dementia. Clinical Interventions in Aging, 15, 849–865. PubMed
14. Green, R. J., & Azzam, S. (2022). Mitochondrial dysfunction in neurodegenerative disease: New insights and therapeutic approaches. Biology of Aging & Chronic Disease, 2, 101108. PubMed
15. Gupta, R., & Kapoor, M. (2020). Role of oxidative stress in Alzheimer's disease: Therapeutic implications. Annals of Neurosciences, 27(4), 179–183. PubMed
16. Gültekin, H., & Bozkurt, B. (2020). Mitochondrial dysfunction in neurodegenerative diseases. Molecular Biology Reports, 47(12), 9579–9593. PubMed
17. iüLabs. (n.d.). Natural supplement drinks | Powerful formulations. iüLabs UK. Retrieved from https://iulabs.co/
18. Jang, H., & Park, J. (2022). Oxidative stress and neuroinflammation in Parkinson’s disease. Frontiers in Neuroscience, 16, 849643. PubMed
19. MetrioPharm AG. (2021, August 19). Thomas Christély joins management of MetrioPharm AG as CEO. MetrioPharm. Retrieved from https://www.metriopharm.com/en/news/2021/Press-Release-Thomas-Christely-joins-management-of-MetrioPharm-AG-as-CEO.html
20. MetrioPharm AG. (n.d.). Management and board. MetrioPharm. Retrieved from https://www.metriopharm.com/en/about-us/Management-and-Board.html
21. Nussbaum, R. L., & Ellis, C. E. (2020). Alzheimer’s disease and neurodegenerative diseases. The Lancet Neurology, 19(11), 951–960. PubMed
22. Perricone, C., & Pizzimenti, S. (2021). The role of oxidative stress in the pathogenesis of multiple sclerosis. Neurochemical Research, 46(1), 67–82. PubMed
23. Polidori, M. C., & Mecocci, P. (2021). Antioxidants and mitochondrial dysfunction in Alzheimer’s disease. Current Medicinal Chemistry, 28(1), 1–14. PubMed
24. Puglisi-Allegra, S., & Cabib, S. (2020). Dopaminergic systems and aging: Oxidative stress and neuroprotection. Ageing Research Reviews, 60, 101081. PubMed
25. Reeve, A., & Keshavarzian, A. (2020). Mitochondrial dysfunction in Parkinson's disease: Relevance to inflammation. Brain Research Bulletin, 160, 95–103. PubMed
26. Sugimoto, M., & Maeda, Y. (2022). Parkinson’s disease and oxidative stress: New therapeutic strategies. Frontiers in Neurology, 13, 801874. PubMed
27. Valdés, J. A., & McNeill, J. (2021). Natural compounds in the prevention of Alzheimer's disease: An evidence-based review. Frontiers in Aging Neuroscience, 13, 721705. PubMed
28. Zhang, Z., & Yu, J. (2021). Mitochondrial dysfunction and neurodegenerative diseases. Neurodegenerative Diseases, 21(1), 1–16. PubMed